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This chapter will develop a comprehensive review of methamphetamine usage with a concentration on North America. To develop a wider understanding of the use of this drug, this chapter will examine the history and spatial component of methamphetamine. In order to achieve this, the research will review previous literature, which includes the pattern of its original manufacture in the United States to international locations such as Mexico. The research data will include two interviews with individuals involved in the underworld of meth use in Los Angeles. The chapter will then present outcomes based on the participant survey and secondary sources.